NR3C1 (Ab-211) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | GCR, GRL, GRL1, NR3C1, glucocorticoid receptor | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P04150 | | Иммуноген | Synthesized non-phosphopeptide derived from human GR around the phosphorylation site of serine 211 (N-E-S-P-W). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic genes expression.<br/><br/>Zhen Wang, Mol. Endocrinol., Mar 2007, 21: 625 - 634.<br/>Aaron L. Miller, Mol. Endocrinol., Jun 2005, 19: 1569 - 1583.<br/>Paul J. LeBlanc, J. Physiol., Jun 2004, 557: 559 - 570.<br/>Jos篓 Xavier-Neto, Hypertension, Jul 1999, 34: 31. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GR (Ab-211) antibody.
 | Immunofluorescence analysis of A549 cells, using GR (Ab-211) antibody.
 | Western blot analysis of extracts from HeLa cells treated with PMA (125ng/ml, 30min), using GR (Ab-211) antibody.
 | Western blot analysis of extracts from K562 cells (Lane 2), using GR (Ab-211) antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: NR3C1 (Ab-211) Antibody.