PAWR AntibodyСпецификация| Объем | 100 мкл | | Синонимы | PAR4, PRKC apoptosis WT1 regulator protein, PRKC, apoptosis, WT1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q96IZ0 | | Иммуноген | Synthesized peptide derived from human prostate apoptosis response protein-4. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Pro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down-regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.<br/><br/>Hongzhe Li, J. Biol. Chem., Feb 2007, 282: 4943 - 4950. <br/>Wuhan Xiao, Cancer Res., Aug 2003, 63: 4698 - 4704. <br/>Thierry Virolle, J. Biol. Chem., Mar 2003, 278: 11802 - 11810. <br/>Derek J. Richard, Genes & Dev., Feb 2001, 15: 328. <br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using Prostate Apoptosis Response Protein-4 antibody.
 | Western blot analysis of extracts from NIH/3T3 cells, using Prostate Apoptosis Response Protein-4 antibody.
 | Western blot analysis of extracts from 293 cells(Lane 2), using Prostate Apoptosis Response Protein-4 antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: PAWR Antibody.