Phospho-NFKB1 (Ser927) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | DNA-binding factor KBF1, EBP-1, NF-kappa-B1 p84/NF-kappa-B1 p98, NFKB1, NFkB-p50 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P19838 | | Иммуноген | Peptide sequence around phosphorylation site of serine 927 (C-D-S(p)-G-V) derived from Human NFkB-p105. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:1000, IHC:1:50-1:100, IF:1:100-1:200 | | Примечание | <p>NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. <br /><br />Hou S, et al. (2003) J Biol Chem. 278(46): 45994-45998. <br />Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179. <br />Baeuerle P A, et al. (1996) Cell 87:13-20. <br />Haskill S, et al. (1991) Cell 65:1281-1289. <br /> ,</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser927 | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HL60 cells untreated or treated with TNF-a using NFkB-p105(Phospho-Ser927) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p105(Phospho-Ser927) Antibody(left) or the same antibody preincubated with blocking peptide(right).
 | Immunofluorescence staining of methanol-fixed Hela cells using NFkB-p105(Phospho-Ser927) Antibody.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA283590 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-NFKB1 (Ser927) Antibody.
Примечание: дополнительная информация (на английском языке). |
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