| Объем | 100 мкл |
| Синонимы | IKBA, MAD-3, NFKBI |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P25963 |
| Иммуноген | Peptide sequence around phosphorylation site of Tyrosine 305(L-P-Y(p)-D-D) derived from Human I kappaB- alpha. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat, Monkey |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | <p>Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription.</p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Tyr305 |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer,Immunology,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from COS-7 cells using I kappaB- alpha (Phospho-Tyr305) Antibody.The lane on the left is treated with the antigen-specific peptide.
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Наименование: Phospho-NFKBIA (Tyr305) Antibody.