Phospho-PRKCA (Tyr658) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | PKC-alpha, KPCA, PKC III, PKC-A, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P17252 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 658(F-S-Y(p)-V-N) derived from Human PKC . | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells.<br /><br />Finkenzeller G., Nucleic Acids Res. 18:2183-2183(1990).<br />McSwine-Kennick R.L., J. Biol. Chem. 266:15135-15143(1991).<br />Gevaert K., Nat. Biotechnol. 21:566-569(2003)</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr658 | | Области исследований | Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COLO205 cells using PKC ? (Phospho-Tyr658) Antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA060190 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-PRKCA (Tyr658) Antibody.
Примечание: дополнительная информация (на английском языке). |
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