PIAS4 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | PIAS-gamma, PIASG, PIASy, protein inhibitor of activated STAT protein 4, protein inhibitor of activated STAT protein PIASy | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q8N2W9 | | Иммуноген | Synthesized peptide derived from Internal of human PIAS4. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.<br/><br/>Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005, 2005: 456. <br/>Amador Albor, J. Biol. Chem., Sep 2006, 281: 25850 - 25866. <br/>Christina-Maria Hecker, J. Biol. Chem., Jun 2006, 281: 16117 - 16127. <br/>Yun Zhao, Stem Cells, Apr 2007, 10.1634.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PIAS4 antibody.
 | Western blot analysis of extracts from Jurkat cells, using PIAS4 antibody.
 | Western blot analysis of extracts from JK cells (Lane 2), using PIAS4 antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: PIAS4 Antibody.