| Объем | 100 мкл |
| Синонимы | H6, Rho-related GTP-binding protein RhoB, RHOB, ARH6, ARHB |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P62745 |
| Иммуноген | Synthesized peptide derived from internal of human RHOB. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells.<br/><br/>Chardin P., Nucleic Acids Res. 16:2717-2717(1988).<br/>Puhl H.L. III, Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.<br/>Halleck A., Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HepG2 cells and HeLa cells, using RHOB antibody.
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Наименование: RHOB Antibody.