RPS6KA4 (Ab-568) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | EC 2.7.11.1, kinase MSK2, KS6A4, Ribosomal protein kinase B, RPS6KA4 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O75676 | | Иммуноген | Synthesized non-phosphopeptide derived from human MSK2 around the phosphorylation site of threonine 568 (M-Q-T(p)-P-C). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.<br/><br/>Pierrat B.,J. Biol. Chem. 273:29661-29671(1998).<br/>Deak M.,EMBO J. 17:4426-4441(1998).<br/>Soloaga A.,EMBO J. 22:2788-2797(2003).<br/> <br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from RAW264.7 cells, treated with UV (5mins), using MSK2 (Ab-568) antibody.
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Наименование: RPS6KA4 (Ab-568) Antibody.