SENP3 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Sentrin-specific protease 3, EC=3.4.22.-, Sentrin/SUMO-specific protease SENP3, SUMO-1-specific protease 3, SSP3 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9H4L4 | | Иммуноген | Synthesized peptide derived from Internal of human SENP3. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Protease that releases SUMO2 and SUMO3 monomers from sumoylated substrates, but has only weak activity against SUMO1 conjugates. Deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability. Deconjugates SUMO2 and SUMO3 from CDCA8. Redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300. Required for rRNA processing through deconjugation of SUMO2 and SUMO3 from nucleophosmin, NPM1. Plays a role in the regulation of sumoylation status of ZNF148. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex, the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.<br/><br/>Yeh E.T.H., Gene 248:1-14(2000).<br/>Choi S.J., Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.<br/>Wiemann S., Genome Res. 11:422-435(2001).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Jurkat cells, using SENP3 antibody.
 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using SENP3 antibody.
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Наименование: SENP3 Antibody.