| Объем | 100 мкл |
| Синонимы | Shugoshin-like 1, hSgo1, Serologically defined breast cancer antigen NY-BR-85, SGO1, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q5FBB7 |
| Иммуноген | Synthesized peptide derived from internal of human SGOL1. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB,WB:1:500-1:3000 |
| Примечание | Plays a central role in chromosome cohesion during mitosis by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by preventing phosphorylation of the STAG2 subunit of cohesin complex at the centromere, ensuring cohesin persistence at centromere until cohesin cleavage by ESPL1/separase at anaphase. Essential for proper chromosome segregation during mitosis and this function requires interaction with PPP2R1A. Its phosphorylated form is necessary for chromosome congression and for the proper attachment of spindle microtubule to the kinetochore. Necessary for kinetochore localization of PLK1 and CENPF. May play a role in the tension sensing mechanism of the spindle-assembly checkpoint by regulating PLK1 kinetochore affinity. Isoform 3 plays a role in maintaining centriole cohesion involved in controlling spindle pole integrity.<br/><br/>McGuinness B.E., PLoS Biol. 3:433-449(2005).<br/>Kitajima T.S., Curr. Biol. 15:353-359(2005).<br/>Tang Z., Proc. Natl. Acad. Sci. U.S.A. 101:18012-18017(2004). |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HeLa cells, using SGOL1 antibody.
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Наименование: SGOL1 Antibody.