TWIST1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | SCS, ACS3, CRS1, BPES2, BPES3 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q15672 | | Иммуноген | Peptide sequence around aa.18~22(S-N-S-E-E) derived from Human Twist1 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | <p>Acts as a transcriptional regulator. Inhibits myogenesis by sequestrating E proteins, inhibiting trans-activation by MEF2, and inhibiting DNA-binding by MYOD1 through physical interaction. This interaction probably involves the basic domains of both proteins. Also represses expression of proinflammatory cytokines such as TNFA and IL1B. Regulates cranial suture patterning and fusion. Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer composition. Homodimers induce expression of FGFR2 and POSTN while heterodimers repress FGFR2 and POSTN expression and induce THBS1 expression. Heterodimerization is also required for osteoblast differentiation.</p><p>",Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity.",Sosic D., Richardson J.A., Yu K., Ornitz D.M., Olson E.N.Cell 112:169-180(2003) , <br />",Mutations of the TWIST gene in the Saethre-Chotzen syndrome.",el Ghouzzi V., le Merrer M., Perrin-Schmitt F., et al., Nat. Genet. 15:42-46(1997)</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Cardiovascular,Developmental biology,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from JK, Raji and HL-60 cells using Twist1 Antibody.
 | Twist1 Antibody staining Twist in Mouse pancreatic cancer tissue sections by Immunohistochemistry
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Наименование: TWIST1 Antibody.