GRIA2 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | glutamate receptor, ionotropic, AMPA 2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P42262 | | Иммуноген | Synthetic peptide of human GRIA2 | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, IHC,ELISA:1:1000-1:5000, IHC:1:25-1:100 | | Примечание | Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG, Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Neuroscience | | Ссылка на страницу на сайте производителя | ссылка | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using CSB-PA099037(GRIA2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ?200)
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastic cancer tissue using CSB-PA099037(GRIA2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ?200)
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Наименование: GRIA2 Antibody.