XAF1 Antibody, Biotin conjugated

Спецификация

Объем	100 мкг
Синонимы	XIAP-associated factor 1 (BIRC4-binding protein), XAF1, BIRC4BP XIAPAF1
Клональность	Polyclonal Antibody
Организм	Human
uniprot	Q6GPH4
Иммуноген	Recombinant Human XIAP-associated factor 1 protein (172-259AA)
Источник	Rabbit
Видовая специфичность	Human
Применение	ELISA
Примечание	Seems to function as a negative regulator of members of the IAP (inhibitor of apoptosis protein) family. Inhibits anti-caspase activity of BIRC4. Induces cleavage and inactivation of BIRC4 independent of caspase activation. Mediates TNF-alpha-induced apoptosis and is involved in apoptosis in trophoblast cells. May inhibit BIRC4 indirectly by activating the mitochondrial apoptosis pathway. After translocation to mitochondra, promotes translocation of BAX to mitochondria and cytochrome c release from mitochondria. Seems to promote the redistribution of BIRC4 from the cytoplasm to the nucleus, probably independent of BIRC4 inactivation which seems to occur in the cytoplasm. The BIRC4-XAF1 complex mediates down-regulation of BIRC5/survivin, the process requires the E3 ligase activity of BIRC4. Seems to be involved in cellular sensitivity to the proapoptotic actions of TRAIL. May be a tumor suppressor by mediating apoptosis resistance of cancer cells.
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Biotin
Буффер	Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Форма	Liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	>95%, Protein G purified
Абревеатура	XIAP-associated factor 1
Области исследований	Cell biology
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Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:	Антитела
	Объем:	100 мкг
	Кат. номер:	CSB-PA764111LD01HU
Цена (с НДС 20%):	по запросу	В корзину
Наименование: XAF1 Antibody, Biotin conjugated. Примечание: дополнительная информация (на английском языке).