| Объем | 100 мкг |
| Синонимы | Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein), KIDINS220, ARMS KIAA1250 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9ULH0 |
| Иммуноген | Recombinant Human Kinase D-interacting substrate of 220 kDa protein (1077-1370AA) |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC, IF, Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Примечание | Promotes a prolonged MAP-kinase signaling by neurotrophins through activation of a Rap1-dependent mechanism. Provides a docking site for the CRKL-C3G complex, resulting in Rap1-dependent sustained ERK activation. May play an important role in regulating postsynaptic signal transduction through the syntrophin-mediated localization of receptor tyrosine kinases such as EPHA4. In cooperation with SNTA1 can enhance EPHA4-induced JAK/STAT activation. Plays a role in nerve growth factor (NGF)-induced recruitment of RAPGEF2 to late endosomes and neurite outgrowth. May play a role in neurotrophin- and ephrin-mediated neuronal outgrowth and in axon guidance during neural development and in neuronal regeneration (By similarity). Modulates stress-induced apoptosis of melanoma cells via regulation of the MEK/ERK signaling pathway. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | >95%, Protein G purified |
| Абревеатура | Kinase D-interacting substrate of 220 kDa |
| Области исследований | Neuroscience, Cardiovascular, Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western Blot
Positive WB detected in: Hela whole cell lysate, HEK293 whole cell lysate
All lanes: KIDINS220 antibody at 3µg/ml
Secondary
Goat polyclonal to rabbit IgG at 1/50000 dilution
Predicted band size: 197, 186, 116, 195, 60 kDa
Observed band size: 197 kDa
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA012306LA01HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human appendix tissue using CSB-PA012306LA01HU at dilution of 1:100
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Immunofluorescent analysis of HepG2 cells using CSB-PA012306LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Наименование: KIDINS220 Antibody.