| Объем | 100 мкл |
| Синонимы | hKSR2, Kinase suppressor of Ras 2, KSR2, |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q6VAB6 |
| Иммуноген | Synthesized peptide derived from internal of human KSR2. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 |
| Примечание | <p>Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.<br /><br />Ota T., Nat. Genet. 36:40-45(2004).<br />Scherer S.E., Nature 440:346-351(2006).<br />Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003).</p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from COS7, 293 and 3T3 cells, using KSR2 antibody.
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Immunofluorescence analysis of HeLa cells, using KSR2 antibody.
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Наименование: KSR2 Antibody.