LCN2 AntibodyСпецификация| Объем | 50 мкг | | Синонимы | Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin LCN2) (p25), LCN2, HNL NGAL | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P80188 | | Иммуноген | Recombinant Human NGAL protein (1-198AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, Recommended dilution: WB:1:1000-1:5000 | | Примечание | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis. Involved in innate immunity, possibly by sequestrating iron, leading to limit bacterial growth. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Области исследований | Cancer, Cardiovascular, Immunology, Metabolism, Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot
All lanes: NGAL antibody at 2µg/ml + positive serum
Lane 1: positive serum at 1: 10
Lane 2: positive serum at 1: 50
Secondary
Goat polyclonal to rabbit IgG at 1/15000 dilution
Predicted band size: 22 kDa
Observed band size: 22 kDa
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Информация для заказа |
Наименование: LCN2 Antibody.