MCM3AP AntibodyСпецификация| Объем | 100 мкл | | Синонимы | 80 kda MCM3-associated protein, GANP protein, KIAA0572, MAP80, MCM3A | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O60318 | | Иммуноген | Synthesized peptide derived from human GANP. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 | | Примечание | Isoform GANP:Essential for the generation of high-affinity B-cells against T-cell-dependent antigens by affecting somatic hypermutation at the IgV-regions. May have stimulation-dependent DNA primase activity that would generate extra RNA primers in very rapidely proliferating cells and would support clonal expansion of differentiating B-cells By similarity. Involved in the nuclear export of poly(A)-containing mRNAs by acting as a scaffold for the TREX-2 complex. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Isoform MCM3AP:Acetyltransferase targeting MCM3. Inhibits initiation of DNA replication, but not elongation.<br/><br/>Nobuo Sakaguchi, J. Immunol., Apr 2005, 174: 4485 - 4494.<br/>Kazuhiko Kuwahara, Blood, Apr 2000, 95: 2321 - 2328.<br/>Y Kono, K Maeda, Genes Cells, Aug 2002, 7: 821 - 834.<br/>Kazuhiko Kuwahara, PNAS, Aug 2001, 98: 10279.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using GANP antibody.
 | Western blot analysis of extracts from NIH/3T3 cells, using GANP antibody.
 | Western blot analysis of extracts from HepG2 cells (Lane 2) and A549 cells (Lane 3), using GANP antiobdy. The lane on the left is treated with synthesized peptide.
 | | | |
Информация для заказа |
Наименование: MCM3AP Antibody.