| Объем | 100 мкл |
| Синонимы | Mediator of RNA polymerase II transcription subunit 23, Mediator complex subunit 23, CRSP complex subunit 3, Cofactor required for Sp1 transcriptional activation subunit 3, Transcriptional coactivator CRSP130 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q9ULK4 |
| Иммуноген | Synthesized peptide derived from internal of human MED23. |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC, IF,WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500 |
| Примечание | Required for transcriptional activation subsequent to the assembly of the preinitiation complex By similarity. Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling.<br/><br/>Wiemann S., Genome Res. 11:422-435(2001).<br/>Mungall A.J., Nature 425:805-811(2003).<br/>Akoulitchev S., Nature 407:102-106(2000).<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Области исследований | Epigenetics and Nuclear Signaling,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from A549 cells, using MED23 antiobdy.
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MED23 antibody.
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Immunofluorescence analysis of A549 cells, using MED23 antibody.
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Наименование: MED23 Antibody.