MEF2C AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Myocyte-specific enhancer factor 2C, MEF2C, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q06413 | | Иммуноген | Synthesized peptide derived from internal of human MEF2C. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, IHC,IHC:1:50-1:100 | | Примечание | Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture By similarity. Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.<br/><br/>Leifer D., Proc. Natl. Acad. Sci. U.S.A. 90:1546-1550(1993).<br/>McDermott J.C., Mol. Cell. Biol. 13:2564-2577(1993).<br/>Wang A.H., Mol. Cell. Biol. 19:7816-7827(1999).<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cardiovascular,Signal transduction,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using MEF2C antibody.
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Наименование: MEF2C Antibody.