MOB1B AntibodyСпецификация| Объем | 100 мкл | | Синонимы | MATS2, MOB1, Mps One Binder kinase activator-like 1A, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q7L9L4 | | Иммуноген | Synthesized peptide derived from internal of human MOL1A. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.<br/><br/>Florindo C.S., Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases<br/>The MGC Project Team, Genome Res. 14:2121-2127(2004).<br/>Devroe E., J. Biol. Chem. 279:24444-24451(2004). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from 293 cells, COS-7 cells and HUVEC cells all treated with IFN (2500U/ml, 30mins), using MOL1A antibody.
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Наименование: MOB1B Antibody.