| Объем | 50 мкл |
| Синонимы | E3 ubiquitin-protein ligase MYLIP (EC 2.3.2.27) (Inducible degrader of the LDL-receptor) (Idol) (Myosin regulatory light chain interacting protein) (MIR) (RING-type E3 ubiquitin transferase MYLIP), MYLIP, BZF1 IDOL |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q8WY64 |
| Иммуноген | Recombinant Human E3 ubiquitin-protein ligase MYLIP protein (266-445AA) |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC, Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200 |
| Примечание | E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of myosin regulatory light chain (MRLC), LDLR, VLDLR and LRP8. Activity depends on E2 enzymes of the UBE2D family. Proteasomal degradation of MRLC leads to inhibit neurite outgrowth in presence of NGF by counteracting the stabilization of MRLC by saposin-like protein (CNPY2/MSAP) and reducing CNPY2-stimulated neurite outgrowth. Acts as a sterol-dependent inhibitor of cellular cholesterol uptake by mediating ubiquitination and subsequent degradation of LDLR. |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen Affinity Purified |
| Абревеатура | E3 ubiquitin-protein ligase MYLIP |
| Области исследований | Epigenetics and Nuclear Signaling, Cancer, Cardiovascular, Cell biology, Metabolism, Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot
All lanes: MYLIP antibody at 4.06 µg/ml
Lane 1: Mouse brain tissue
Lane 2: Mouse liver tissue
Lane 3: Mouse spleen tissue
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 50, 15 kDa
Observed band size: 50 kDa
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Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA855506ESR2HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA855506ESR2HU at dilution of 1:100
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Наименование: MYLIP Antibody.