NEUROD1 (Ab-274) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Neurogenic differentiation factor 1, NEUROD1, NEUROD, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q13562 | | Иммуноген | Synthesized non-phosphopeptide derived from human Neuro D around the phosphorylation site of serine 272 (P-L-S(p)-P-P-). | | Источник | Rabbit | | Видовая специфичность | Human, Mouse | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis By similarity.<br/><br/>Tamimi R., Genomics 34:418-421(1996).<br/>Yokoyama M., Brain Res. Mol. Brain Res. 42:135-139(1996).<br/>Miyachi T., Brain Res. Mol. Brain Res. 69:223-231(1999)<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Cardiovascular,Metabolism | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HeLa cells, using Neuro D (Ab-274) antibody.
 | | | |
Информация для заказа |
Наименование: NEUROD1 (Ab-274) Antibody.