NEUROD2 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | Neurogenic differentiation factor 2, NeuroD2, NeuroD-related factor, NDRF, NEUROD2 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q15784 | | Иммуноген | Synthesized peptide derived from internal of human NDF2. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:3000 | | Примечание | Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation, prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections, involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter By similarity.<br/><br/>McCormick M.B., Mol. Cell. Biol. 16:5792-5800(1996). <br/>Kitamura T., Biochim. Biophys. Acta 1445:142-147(1999). <br/>The MGC Project Team, Genome Res. 14:2121-2127(2004). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Stem cells | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from COLO cells, Jurkat cells and 293 cells, using NDF2 antibody.
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Наименование: NEUROD2 Antibody.