NFKB1 (Ab-337) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | DNA-binding factor KBF1, EBP-1, NF-kappa-B1 p84/NF-kappa-B1 p98, NFKB1, NFkB-p50 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P19838 | | Иммуноген | Peptide sequence around aa.335~339 (R-K-S-D-L) derived from Human NFkB-p105. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 | | Примечание | NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.<br/><br/>Hou S, et al. (2003) J Biol Chem. 278(46): 45994-45998.<br/>Baeuerle P A, et al. (1994) Annu Rev Immunol. 12:141-179.<br/>Baeuerle P A, et al. (1996) Cell 87:13-20.<br/>Haskill S, et al. (1991) Cell 65:1281-1289.<br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology,Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HT29 cells using NFkB-p105/p50(Ab-337) Antibody and the same antibody preincubated with blocking peptide.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p105/p50(Ab-337) Antibody(left) or the same antibody preincubated with blocking peptide(right).
 | | | |
Информация для заказа |
Наименование: NFKB1 (Ab-337) Antibody.