NLRP3 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | NLR family, pyrin domain containing 3 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q96P20 | | Иммуноген | Fusion protein of human NLRP3 | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB,ELISA:1:1000-1:2000, WB:1:200-1:1000 | | Примечание | This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data, however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antigen affinity purification | | Области исследований | Cancer,Cardiovascular,Immunology,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Gel: 8%SDS-PAGE, Lysate: 40 ?g, Lane 1-2: K562 cells, hela cells, Primary antibody: CSB-PA993403(NLRP3 Antibody) at dilution 1/88, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
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Наименование: NLRP3 Antibody.