PGR (Ab-190) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | NR3C3, PGR, PRGR | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P06401 | | Иммуноген | Peptide sequence around aa.188~192 (G-L-S-P-A) derived from Human Progesterone Receptor. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IF,WB:1:500-1:1000, IF:1:100-1:200 | | Примечание | <p>Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22. <br /><br />Narayanan R, et al. (2005) Mol Cell Biol, 25(8): 2885-98. <br />Knotts TA, et al. (2001) J Biol Chem, 276(11): 8475-83. <br />Clemm DL, et al. (2000) Mol Endocrinol, 14(1): 52-65. <br />Zhang Y, et al. (1997) Mol Endocrinol, 11(6): 823-32</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from MDA435 cells using Progesterone Receptor(Ab-190) Antibody.
 | Immunofluorescence staining of methanol-fixed Hela cells using Progesterone Receptor(Ab-190) Antibody.
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Наименование: PGR (Ab-190) Antibody.