Phospho-CREB1 (Ser133) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | CREB-1, CREB1, | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P16220 | | Иммуноген | Peptide sequence around phosphorylation site of serine 133 (R-P-S(p)-Y-R) derived from Human CREB. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:100 | | Примечание | <p>CREB1 is a transcription factor that is a member of the bZIP family of DNA binding proteins. It binds as a homodimer to the CRE (cAMP-Responsive Element), an octameric palindrome containing a conserved core sequence, 5-prime-TGACG-3-prime. It consists of two transcript variants encoding respective isoforms produced by alternate splicing. It is mapped to 2q32.3-q34 . It is phosphorylated by several protein kinases and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. CREB1 is crucial for the consolidation of long-term conditioned fear memories, but not for encoding, storage, or retrieval of these memories. It is required for the stability of reactivated or retrieved conditioned fear memories . <br /><br />Xing J, et al. (1998) Mol Cell Biol 18(4): 1946-55. <br />Tan Y, et al. (1996) EMBO J, 15(17): 4629-42. <br />Hao, M. et al. (1996) J. Biol. Chem. 271, 29380-29385. <br />Mayo LD, et al. (2001) Biol Chem, 276(27): 25184-9.</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Ser133 | | Области исследований | Epigenetics and Nuclear Signaling,Immunology | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from Hela cells untreated or treated with UV using CREB(Phospho-Ser133) Antibody.
 | Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB(Phospho-Ser133) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA935267 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-CREB1 (Ser133) Antibody.
Примечание: дополнительная информация (на английском языке). |
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