Phospho-FGFR1 (Tyr766) AntibodyСпецификация| Объем | 100 мкл | | Синонимы | FGFBR, FGFR-1, FLG, FLT2, c-fgr | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P11362 | | Иммуноген | Peptide sequence around phosphorylation site of tyrosine 766 (Q-E-Y(p)-L-D) derived from FGFR1. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB,WB:1:500-1:1000 | | Примечание | <p>Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.<br/><br/>Cross MJ, et al. (2002) Mol Biol Cell 13, 2881-93. Foehr ED, Raffioni S, Murray-Rust J, Bradshaw RA (2001)J Biol Chem 276, 37529-36. Cross MJ, et al. (2000)J Cell Sci 113 ( Pt 4), 643-51 .</p> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. | | Абревеатура | Phospho-Tyr766 | | Области исследований | Epigenetics and Nuclear Signaling,Neuroscience,Cancer,Cardiovascular,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from HepG2 cells treated with EGF using Phospho-FGFR1 (Tyr766) antibody.The lane on the right is treated with the antigen-specific peptide.
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Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкл | | Кат. номер: | CSB-PA138978 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: Phospho-FGFR1 (Tyr766) Antibody.
Примечание: дополнительная информация (на английском языке). |
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