Phospho-NTRK1 (Tyr680/681) Antibody

Спецификация

Объем	100 мкл
Синонимы	High affinity nerve growth factor receptor precursor, NTRK1, Slow nerve growth, TRK, Trk-A
Клональность	Polyclonal Antibody
Организм	Human
uniprot	P04629
Иммуноген	Peptide sequence around phosphorylation site of tyrosine 680/tyrosine 681 (T-D-Y(p)-Y(p)-R-V) derived from Human Trk A.
Источник	Rabbit
Видовая специфичность	Human, Mouse, Rat
Применение	ELISA, WB,WB:1:500-1:1000
Примечание	<p>Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.<br/><br/>Liu HY, et al. (2005) J Biol Chem 280, 19461-71 <br />Wahab NA, Weston BS, Mason RM (2005) J Am Soc Nephrol 16, 340-51 <br />Marsh HN, et al. (2003) J Cell Biol 163, 999-1010</p>
Клональность1	Polyclonal
Изотип	IgG
Коньюгат	Non-conjugated
Буффер	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Форма	liquid
Хранение	Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Метод очистки	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Абревеатура	Phospho-Tyr680/681
Области исследований	Others
Ссылка на страницу на сайте производителя	ссылка
Western blot analysis of extracts from Jurkat cells treated with starved using Phospho-Trk A (Tyr680/Tyr681) antibody.The lane on the right is treated with the antigen-specific peptide.

Информация для заказа

Область использования: Поликлональные антитела Cusabio	Производство:	Cusabio
	Метод:	Антитела
	Объем:	100 мкл
	Кат. номер:	CSB-PA095633
Цена (с НДС 20%):	по запросу	В корзину
Наименование: Phospho-NTRK1 (Tyr680/681) Antibody. Примечание: дополнительная информация (на английском языке).