| Объем | 100 мкл |
| Синонимы | FAK, FAK1, PTK2 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | Q05397 |
| Иммуноген | Peptide sequence around phosphorylation site of tyrosine 397(D-D-Y(p)-A-E)derived from Human FAK. |
| Источник | Rabbit |
| Видовая специфичность | Human, Rat |
| Применение | ELISA, WB,WB:1:500-1:1000 |
| Примечание | Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Microtubule-induced dephosphorylation at Tyr-397 is crucial for the induction of focal adhesion disassembly. Plays a potential role in oncogenic transformations resulting in increased kinase activity.<br/><br/>Matsuya M.et.al. (1998)J. Biol. Chem. 273:1003-1014<br/>Fujita H.et.al. (1998)J. Biol. Chem. 273:26516-26521<br/>Le Romancer M.et.al. (2008)Mol. Cell 31:212-221<br/> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Tyr397 |
| Области исследований | Cancer,Cardiovascular,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extract from 293 cells untreated or treated with EGF using FAK(Phospho-Tyr397) Antibody using
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Наименование: Phospho-PTK2 (Tyr397) Antibody.