| Объем | 100 мкл |
| Синонимы | E12, Tran, TCF3, TFE2, ITF1 |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P15923 |
| Иммуноген | Peptide sequence around phosphorylation site of threonine 355 (P-S-T(p)-P-V) derived from Human E2A . |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse, Rat |
| Применение | ELISA, IHC,IHC:1:50-1:100 |
| Примечание | <p>E2A is a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. <br/><br/>Kamps M.P., Cell 60:547-555(1990).<br />Nourse J., Cell 60:535-545(1990).<br />Grimwood J., Nature 428:529-535(2004).<br /></p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide. |
| Абревеатура | Phospho-Thr355 |
| Области исследований | Epigenetics and Nuclear Signaling,Stem cells |
| Ссылка на страницу на сайте производителя | ссылка |
Immunohistochemical analysis of paraffin-embedded human brain tissue using E2A (Phospho-Thr355) antibody (left)or the same antibody preincubated with blocking peptide (right).
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Наименование: Phospho-TCF3 (Thr355) Antibody.