PSEN1 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | AD3, AD3H, PS-1, PS1, PSN1 | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | P49768 | | Иммуноген | Synthesized peptide derived from human presenilin 1. | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA, WB, IHC,WB:1:500-1:3000, IHC:1:50-1:100 | | Примечание | Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.<br/><br/>Yanzhu Liu, J. Lipid Res., Dec 2004, 45: 2368 - 2376. <br/>I. Imafuku, J. Cell Biol., Oct 1999, 147: 121. <br/>Angeliki Louvi, Development, Jul 2004, 131: 3093 - 3105. <br/>Wim G. Annaert, J. Cell Biol., Oct 1999, 147: 277. <br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Neuroscience,Cancer,Metabolism,Signal transduction | | Ссылка на страницу на сайте производителя | ссылка | Western blot analysis of extracts from mouse heart cells, using presenilin 1 antibody.
 | Immunohistochemical analysis of paraffin-embedded human brain tissue using presenilin 1 antibody.
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Наименование: PSEN1 Antibody.