| Объем | 100 мкл |
| Синонимы | Poliovirus receptor (Nectin-like protein 5) (NECL-5) (CD antigen CD155), PVR, PVS |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P15151 |
| Иммуноген | Recombinant Human Poliovirus receptor protein (220-345AA) |
| Источник | Rabbit |
| Видовая специфичность | Human, Mouse |
| Применение | ELISA, WB, IHC, Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 |
| Примечание | Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to the microtubular network through interaction with DYNLT1. This interaction would drive the virus-containing vesicle to the axonal retrograde transport.2 Publications |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Форма | Liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antigen Affinity Purified |
| Области исследований | Microbiology |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot
All lanes: Poliovirus receptor antibody at 3µg/ml
Lane 1: Mouse gonad tissue
Lane 2: HepG2 whole cell lysate
Lane 3: K562 whole cell lysate
Secondary
Goat polyclonal to rabbit IgG at 1/10000 dilution
Predicted band size: 46, 41, 40, 43 kDa
Observed band size: 46 kDa
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Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA019093ESR1HU at dilution of 1:100
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Наименование: PVR Antibody.