SNAI2 Antibody, Biotin conjugatedСпецификация| Объем | 100 мкг | | Синонимы | Zinc finger protein SNAI2 (Neural crest transcription factor Slug) (Protein snail homolog 2), SNAI2, SLUG SLUGH | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | O43623 | | Иммуноген | Recombinant Human Zinc finger protein SNAI2 protein (12-124AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | Transcriptional repressor that modulates both activator-dependent and basal transcription. Involved in the generation and migration of neural crest cells. Plays a role in mediating RAF1-induced transcriptional repression of the TJ protein, occludin (OCLN) and subsequent oncogenic transformation of epithelial cells (By similarity). Represses BRCA2 expression by binding to its E2-box-containing silencer and recruiting CTBP1 and HDAC1 in breast cells. In epidermal keratinocytes, binds to the E-box in ITGA3 promoter and represses its transcription. Involved in the regulation of ITGB1 and ITGB4 expression and cell adhesion and proliferation in epidermal keratinocytes. Binds to E-box2 domain of BSG and activates its expression during TGFB1-induced epithelial-mesenchymal transition (EMT) in hepatocytes. Represses E-Cadherin/CDH1 transcription via E-box elements. Involved in osteoblast maturation. Binds to RUNX2 and SOC9 promoters and may act as a positive and negative transcription regulator, respectively, in osteoblasts. Binds to CXCL12 promoter via E-box regions in mesenchymal stem cells and osteoblasts. Plays an essential role in TWIST1-induced EMT and its ability to promote invasion and metastasis. | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Biotin | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Zinc finger protein SNAI2 | | Области исследований | Epigenetics and Nuclear Signaling, Neuroscience, Cancer, Developmental biology, Stem cells | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкг | | Кат. номер: | CSB-PA021869LD01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: SNAI2 Antibody, Biotin conjugated.
Примечание: дополнительная информация (на английском языке). |
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