| Объем | 100 мкл |
| Синонимы | IL-4 Stat |
| Клональность | Polyclonal Antibody |
| Организм | Human |
| uniprot | P42226 |
| Иммуноген | Peptide sequence around aa.639~643 (R-G-Y-V-P) derived from Human STAT6. |
| Источник | Rabbit |
| Видовая специфичность | Human |
| Применение | ELISA, WB, IHC,WB:1:500-1:1000, IHC:1:50-1:200 |
| Примечание | <p>STAT6 is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor-associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. By screening an embryonic lung fibroblast cDNA library with a wildtype STAT6 probe, 2 variant cDNAs were identified, which were termed STAT6B and STAT6C, encoding an N-terminal 110-amino acid truncation and a 27-amino acid deletion in the SH2 domain, respectively. All the three variants are ubiquitously expressed with STAT6B expression greatest in spleen and STAT6C expression greatest in lung. STAT6B resembles an attenuated STAT6, but that STAT6C inhibits IL-4-mediated mitogenesis and cell surface antigen expression, and is not tyrosine phosphorylated <br /><br />Nelms K, et al. (1999) Annu Rev Immunol. 17:701-738. <br />Malabarba M G, et al. (1996) Biochem. J. 319:865-872. <br />Hou J, et al. (1994) Science. 265:1701-1706. <br />Quelle F W, et al. (1995) Mol Cell Biol. 15: 3336-3343. <br />Takeda K, et al. (1996) Nature. 380: 627-630. </p> |
| Клональность1 | Polyclonal |
| Изотип | IgG |
| Коньюгат | Non-conjugated |
| Буффер | Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Форма | liquid |
| Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. |
| Метод очистки | Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. |
| Области исследований | Epigenetics and Nuclear Signaling,Cancer,Signal transduction |
| Ссылка на страницу на сайте производителя | ссылка |
Western blot analysis of extracts from HepG2 cells using STAT6(Ab-641) Antibody.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using STAT6(Ab-641) Antibody(left) or the same antibody preincubated with blocking peptide(right).
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Наименование: STAT6 (Ab-641) Antibody.