TP63 AntibodyСпецификация| Объем | 100 мкл | | Синонимы | EEC3, KET, LMS, SHFM4, TA p63 alpha | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q9H3D4 | | Иммуноген | Synthesized peptide derived from human p63 antibody. | | Источник | Rabbit | | Видовая специфичность | Human, Mouse, Rat | | Применение | ELISA, WB, IF,WB:1:500-1:3000, IF:1:100-1:500 | | Примечание | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specificactivity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TAx-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.<br/><br/>Pranay C. Patel, Arch Otolaryngol Head Neck Surg, May 1998, 124: 559. <br/>Atul A. Gawande, Arch Surg, Apr 2006, 141: 381 - 384. <br/>Timothy M. Murray, Endocr. Rev., Feb 2005, 26: 78 - 113. <br/>W. M. Philbrick, Physiol Rev, Jan 1996, 76: 127. <br/><br/> | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Non-conjugated | | Буффер | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. | | Форма | liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. | | Области исследований | Epigenetics and Nuclear Signaling,Cancer,Cell biology | | Ссылка на страницу на сайте производителя | ссылка | Immunofluorescence analysis of A549 cells, using p63 antibody.
 | Western blot analysis of extracts from COS7 cells, using p63 antibody.
 | Western blot analysis of extracts from HuvEc cells (Lane 2), JK cells (Lane 3) and cos-7 cells (Lane4), using p63 antiobdy. The lane on the left is treated with synthesized peptide.
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Наименование: TP63 Antibody.