UBE3A Antibody, Biotin conjugatedСпецификация| Объем | 100 мкг | | Синонимы | Ubiquitin-protein ligase E3A (EC 2.3.2.26) (E6AP ubiquitin-protein ligase) (HECT-type ubiquitin transferase E3A) (Human papillomavirus E6-associated protein) (Oncogenic protein-associated protein E6-AP) (Renal carcinoma antigen NY-REN-54), UBE3A, E6AP EPVE6AP HPVE6A | | Клональность | Polyclonal Antibody | | Организм | Human | | uniprot | Q05086 | | Иммуноген | Recombinant Human Ubiquitin-protein ligase E3A protein (83-234AA) | | Источник | Rabbit | | Видовая специфичность | Human | | Применение | ELISA | | Примечание | E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). | | Клональность1 | Polyclonal | | Изотип | IgG | | Коньюгат | Biotin | | Буффер | Preservative: 0.03% Proclin 300<br />Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 | | Форма | Liquid | | Хранение | Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. | | Метод очистки | >95%, Protein G purified | | Абревеатура | Ubiquitin-protein ligase E3A | | Области исследований | Epigenetics and Nuclear Signaling, Neuroscience, Cell biology | | Ссылка на страницу на сайте производителя | ссылка | | | |
Информация для заказа| Область использования: | Производство: | Cusabio | | Метод: | Антитела | | Объем: | 100 мкг | | Кат. номер: | CSB-PA025488LD01HU | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: UBE3A Antibody, Biotin conjugated.
Примечание: дополнительная информация (на английском языке). |
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