anti- APP antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human, Pig | | Tested Application | ELISA, WB, IHC | | Delivery Time | 2 to 4 working days | | Clone ID | 8B9 | | Isotype | IgG2a | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | P05067 | | Gene ID | | | Calculated MW | 100 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts.
The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis.
| | Immunogen | amyloid beta A4 precursor protein | | Synonyms | A4, ABPP,Alzheimer disease amyloid protein,Cerebral vascular amyloid peptide,Beta-amyloid precursor protein,
CVAP,PreA4 | | Recommended dilution | WB: 1:500-1:2000; IHC: 1:50-1:500 | Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab00513(APP Antibody) at dilution of 1:200
 | HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00513(APP Antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab00513 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- APP antibody.
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