| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human |
| Tested Application | ELISA, WB, IHC |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | O14862 |
| Gene ID | |
| Calculated MW | 40 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Background | Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8(By similarity). Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity. |
| Immunogen | absent in melanoma 2 |
| Synonyms | Absent in melanoma 2, AIM2, PYHIN4 |
| Recommended dilution | WB: 1:500-1:5000; IHC: 1:20-200 |
Immunohistochemistry of paraffin-embedded human testis using FNab00238(AIM2 antibody) at dilution of 1:100
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K-562 cells were subjected to SDS PAGE followed by western blot with FNab00238(AIM2 antibody) at dilution of 1:1000
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