| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human, Rat |
| Tested Application | ELISA, IHC, WB, IF |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | P37840 |
| Gene ID | |
| Calculated MW | 15 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| Background | Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. |
| Immunogen | synuclein, alpha (non A4 component of amyloid precursor) |
| Synonyms | Alpha synuclein, NACP, PARK1, PARK4, SNCA |
| Recommended dilution | WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:50 - 1:200 |
Immunohistochemistry of paraffin-embedded human brain using FNab00345(SNCA antibody) at dilution of 1:50
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mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00345(SNCA antibody) at dilution of 1:1000
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