anti- CREST antibody

Спецификация

Clonality	monoclonal
Host	Mouse
Specificity	Human, Mouse, Rat
Tested Application	ELISA, WB
Delivery Time	2 to 4 working days
Clone ID	7A7
Isotype	IgG1
Form	liquid
Purification	Protein A+G purification
Purity	≥95% as determined by SDS-PAGE
Uniprot ID	O75177
Calculated MW	50 kDa
Ссылка на страницу на сайте производителя	ссылка
Инструкция	PDF
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein(CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP(By similarity).
Immunogen	synovial sarcoma translocation gene on chromosome 18-like 1
Synonyms	CREST, KIAA0693, LP2261, SS18 like protein 1, SS18L1, SYT homolog 1
Recommended dilution	WB: 1:1000-1:6000
NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab01972(CREST antibody) at dilution of 1:3000

Информация для заказа

Область использования: Моноклональные антитела	Производство:	Fine Biotech
	Метод:	Антитела
	Объем:	100µg
	Кат. номер:	FNab01972
Цена (с НДС 20%):	по запросу	В корзину
Наименование: anti- CREST antibody. Примечание: