anti- ATF4 antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human, Mouse | | Tested Application | ELISA, IHC, WB, IF | | Delivery Time | 2 to 4 working days | | Clone ID | 0B11 | | Isotype | IgG1 | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | P18848 | | Gene ID | | | Calculated MW | 50-58 kDa, 35-38 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Transcriptional activator. Binds the cAMP response element(CRE)(consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Cooperates with FOXO1 in osteoblasts to regulate glucose homeostasis through suppression of beta-cell production and decrease in insulin production(By similarity). It binds to a Tax-responsive enhancer element in the long terminal repeat of HTLV-I. Regulates the induction of DDIT3/CHOP and asparagine synthetase(ASNS) in response to endoplasmic reticulum(ER) stress. In concert with DDIT3/CHOP, activates the transcription of TRIB3 and promotes ER stress-induced neuronal apoptosis by regulating the transcriptional induction of BBC3/PUMA. Activates transcription of SIRT4. Regulates the circadian expression of the core clock component PER2 and the serotonin transporter SLC6A4. Binds in a circadian time-dependent manner to the cAMP response elements(CRE) in the SLC6A4 and PER2 promoters and periodically activates the transcription of these genes. During ER stress response, activates the transcription of NLRP1, possibly in concert with other factors(PubMed:26086088). | | Immunogen | activating transcription factor 4(tax-responsive enhancer element B67) | | Synonyms | CREB2, TXREB | Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab00663(ATF4 Antibody) at dilution of 1:50 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
 | HepG2 cells were subjected to SDS PAGE followed by western blot with FNab00663(ATF4 Antibody) at dilution of 1:2000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab00663 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- ATF4 antibody.
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