anti- AGER antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human, Rat | | Tested Application | ELISA, WB | | Delivery Time | 2 to 4 working days | | Clone ID | 1B6 | | Isotype | IgG1 | | Form | liquid | | Purification | protein A+G purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q15109 | | Gene ID | | | Calculated MW | 43 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Mediates interactions of advanced glycosylation end products(AGE). These are nonenzymatically glycosylated proteins which accumulate in vascular tissue in aging and at an accelerated rate in diabetes. Acts as a mediator of both acute and chronic vascular inflammation in conditions such as atherosclerosis and in particular as a complication of diabetes. AGE/RAGE signaling plays an important role in regulating the production/expression of TNF-alpha, oxidative stress, and endothelial dysfunction in type 2 diabetes. Interaction with S100A12 on endothelium, mononuclear phagocytes, and lymphocytes triggers cellular activation, with generation of key proinflammatory mediators. Interaction with S100B after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling(By similarity). Receptor for amyloid beta peptide. Contributes to the translocation of amyloid-beta peptide(ABPP) across the cell membrane from the extracellular to the intracellular space in cortical neurons. ABPP-initiated RAGE signaling, especially stimulation of p38 mitogen-activated protein kinase(MAPK), has the capacity to drive a transport system delivering ABPP as a complex with RAGE to the intraneuronal space. Can also bind oligonucleotides. | | Immunogen | advanced glycosylation end product-specific receptor | | Synonyms | AGER, RAGE | | Recommended dilution | WB: 1:1000-1:5000 | Rar lung tissue were subjected to SDS PAGE followed by western blot with FNab09951(AGER Antibody) at dilution of 1:2000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab09951 | | Цена (с НДС 20%): | по запросу | В корзину  |  Наименование: anti- AGER antibody.
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