anti- CD146/MCAM antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human | | Tested Application | ELISA, WB, IHC, FC | | Delivery Time | 2 to 4 working days | | Clone ID | 0E4 | | Isotype | IgG1 | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | P43121 | | Calculated MW | 113-120 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | CD146, also known as melanoma cell adhesion molecule(MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin(Ig) superfamily(PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells(CECs)(PMID: 19356677). | | Immunogen | melanoma cell adhesion molecule | | Synonyms | CD146, MCAM, MUC18,Cell surface glycoprotein MUC18,Cell surface glycoprotein P1H12,Melanoma cell adhesion molecule,Melanoma-associated antigen A32,Melanoma-associated antigen MUC18
| | Recommended dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 | Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab01429(CD146, MCAM Antibody) at dilution of 1:20
 | A375 cells were subjected to SDS PAGE followed by western blot with FNab01429(CD146, MCAM antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab01429 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- CD146/MCAM antibody.
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