anti- ALKBH3 antibodyСпецификация| Clonality | polyclonal | | Host | Rabbit | | Specificity | Human, Mouse | | Tested Application | ELISA, WB, IHC | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q96Q83 | | Gene ID | | | Calculated MW | 33 kDa, observed 25 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Dioxygenase that mediates demethylation of DNA and RNA containing 1-methyladenosine(m1A)(PubMed:12486230, PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410). Repairs alkylated DNA containing 1-methyladenosine(m1A) and 3-methylcytosine(m3C) by oxidative demethylation(PubMed:12486230, PubMed:12594517, PubMed:16174769). Has a strong preference for single-stranded DNA(PubMed:12486230, PubMed:12594517, PubMed:16174769). Able to process alkylated m3C within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3(PubMed:22055184). Also acts on RNA(PubMed:12594517, PubMed:16174769, PubMed:26863196, PubMed:26863410, PubMed:16858410). Demethylates N(1)-methyladenosine(m1A) RNA, an epigenetic internal modification of messenger RNAs(mRNAs) highly enriched within 5'-untranslated regions(UTRs) and in the vicinity of start codons(PubMed:26863196, PubMed:26863410). Requires molecular oxygen, alpha-ketoglutarate and iron(PubMed:22055184, PubMed:16858410). | | Immunogen | alkB, alkylation repair homolog 3(E. coli) | | Synonyms | ABH3, ALKBH3, DEPC 1, DEPC1, FLJ43614, PCA1, Prostate cancer antigen 1 | | Recommended dilution | WB: 1:500-1:5000; IHC: 1:20-1:200 | Immunohistochemistry of paraffin-embedded human lung cancer using FNab00312(ALKBH3 antibody) at dilution of 1:50
 | mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab00312(ALKBH3 antibody) at dilution of 1:1000
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab00312 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- ALKBH3 antibody.
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