anti- CSK antibody

Clonality	monoclonal
Host	Mouse
Specificity	Human
Tested Application	ELISA, WB, IF
Delivery Time	2 to 4 working days
Clone ID	0A11
Isotype	IgG1
Form	liquid
Purification	Protein A+G purification
Purity	≥95% as determined by SDS-PAGE
Uniprot ID	P41240
Gene ID
Calculated MW	50 kDa
Ссылка на страницу на сайте производителя	ссылка
Инструкция	PDF
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth, differentiation, migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases(SFKs) including LCK, SRC, HCK, FYN, LYN or YES1. Upon tail phosphorylation, Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs, CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors, including T-cell receptor(TCR) and B-cell receptor(BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
Immunogen	c-src tyrosine kinase
WB Image

Область использования: Моноклональные антитела	Производство:	Fine Biotech
	Метод:	Антитела
	Объем:	100µg
	Кат. номер:	FNab02017
Цена (с НДС 20%):	по запросу	В корзину
Наименование: anti- CSK antibody. Примечание: