anti- FHIT antibody

Спецификация

Clonality	monoclonal
Host	Mouse
Specificity	Human
Tested Application	ELISA, WB, IF, IHC
Delivery Time	2 to 4 working days
Clone ID	8G4
Isotype	IgG2a
Form	liquid
Purification	Protein A+G purification
Purity	≥95% as determined by SDS-PAGE
Uniprot ID	P49789
Gene ID
Calculated MW	17 kDa
Ссылка на страницу на сайте производителя	ссылка
Инструкция	PDF
Storage	PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Background	Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate(Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate(Ap4A), but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival, such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds, but does not require its catalytic activity, it may in part come from the mitochondrial form, which sensitizes the low-affinity Ca(2+) transporters, enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
Immunogen	fragile histidine triad gene
Immunohistochemistry of paraffin-embedded human breast cancer slide using FNab03108(FHIT Antibody) at dilution of 1:50
K-562 cells were subjected to SDS PAGE followed by western blot with FNab03108(FHIT antibody) at dilution of 1:500

Информация для заказа

Область использования: Моноклональные антитела	Производство:	Fine Biotech
	Метод:	Антитела
	Объем:	100µg
	Кат. номер:	FNab03108
Цена (с НДС 20%):	по запросу	В корзину
Наименование: anti- FHIT antibody. Примечание: