anti- MMS19 antibodyСпецификация| Clonality | monoclonal | | Host | Mouse | | Specificity | Human, Mouse, Rat | | Tested Application | ELISA, WB, IF, IHC | | Delivery Time | 2 to 4 working days | | Clone ID | 6H1 | | Isotype | IgG2a | | Form | liquid | | Purification | Protein A+G purification | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q96T76 | | Gene ID | | | Calculated MW | 103 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery. | | Immunogen | MMS19 nucleotide excision repair homolog(S. cerevisiae) | | Synonyms | MMS19L | Immunohistochemistry of paraffin-embedded human cervical cancer using FNab05249(MMS19 antibody) at dilution of 1:50
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Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab05249 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- MMS19 antibody.
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