anti- NRF2, NFE2L2 antibodyСпецификация| Highlight | Pubmed/Publication | | Clonality | polyclonal | | Host | Rabbit | | Specificity | Human, Mouse, Rat, Zebrafish | | Tested Application | ELISA, IP, WB, IHC, FC | | Delivery Time | 2 to 4 working days | | Isotype | IgG | | Form | liquid | | Purification | Immunogen affinity purified | | Purity | ≥95% as determined by SDS-PAGE | | Uniprot ID | Q16236 | | Calculated MW | 70-100 kDa | | Ссылка на страницу на сайте производителя | ссылка | | Инструкция | PDF | | Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) | | Background | NRF2, also named as NFE2L2, belongs to the bZIP family and CNC subfamily. It is a transcription activator that binds to antioxidant response(ARE) elements in the promoter regions of target genes. NRF2 is important for the coordinated up-regulation of genes in response to oxidative stress. It may be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.Nrf2 is a key player in the regulation of genes encoding for many antioxidative response enzymes.The expression of NRF2 may be induced under oxidative stress(PMID:14567983).In lung cancer, Nrf2 activation in malignant cells has been associated with tumor progression and chemotherapy resistance(PMID:20534738). Identifying patients with abnormal NRF2 expression may be important for selection for chemotherapy in NSCLC. | | Immunogen | nuclear factor(erythroid-derived 2)-like 2 | | Synonyms | HEBP1, NF E2 related factor 2, NFE2 related factor 2, NFE2L2, NRF2 | | Recommended dilution | WB: 1:200-1:2000; IP: 1:200-1:1000; IHC: 1:50-1:500 | Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using FNab05855(NRF2, NFE2L2 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
 | DMSO treated HeLa cells were subjected to SDS PAGE followed by western blot with FNab05855(NRF2, NFE2L2 Antibody) at dilution of 1:600
 | | | |
Информация для заказа| Область использования: | Производство: | Fine Biotech | | Метод: | Антитела | | Объем: | 100µg | | Кат. номер: | FNab05855 | | Цена (с НДС 20%): | по запросу | В корзину  | Наименование: anti- NRF2, NFE2L2 antibody.
Примечание: |
|
