| Clonality | polyclonal |
| Host | Rabbit |
| Specificity | Human |
| Tested Application | ELISA, WB, IHC |
| Delivery Time | 2 to 4 working days |
| Isotype | IgG |
| Form | liquid |
| Purification | Immunogen affinity purified |
| Purity | ≥95% as determined by SDS-PAGE |
| Uniprot ID | O95453 |
| Gene ID | |
| Calculated MW | 90 kDa |
| Ссылка на страницу на сайте производителя | ссылка |
| Инструкция | PDF |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 12 months (Avoid repeated freeze / thaw cycles.) |
| Background | The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that contain premature stop codons. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| Immunogen | poly(A)-specific ribonuclease (deadenylation nuclease) |
| Synonyms | DAN |
| Recommended dilution | WB: 1:1000 - 1:3000; IHC: 1:50 - 1:200 |
Immunohistochemistry of paraffin-embedded human esophageal cancer using FNab06150(PARN antibody) at dilution of 1:100
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MDA-MB-453s cells were subjected to SDS PAGE followed by western blot with FNab06150(PARN antibody) at dilution of 1:1000
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